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Proteintech
Neurofascin Polyclonal Antibody
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Product Details
26351-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Neurofascin Fusion Protein Ag24165 (74-185 aa encoded by BC137013)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RFFNIAKDP RVSMRRRSGT LVIDFRSGGR PEEYEGEYQC FARNKFGTAL SNRIRLQVSK SPLWPKENLD PVVVQEGAPL TLQCNPPPGL PSPVIFWMSS SMEPITQDKR VSQ (74-185 aa encoded by BC137013)
Target Information
Neurofascin encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. Neurofascin undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686P2250; KIAA0756FLJ46866; Neurofascin; neurofascin homolog; unnamed protein product
Gene Aliases: AA387016; D430023G06Rik; KIAA0756; mKIAA0756; NEDCPMD; NF; NFASC; NRCAML
UniProt ID: (Human) O94856, (Rat) P97685, (Mouse) Q810U3
Entrez Gene ID: (Human) 23114, (Rat) 116690, (Mouse) 269116
cell adhesion
axon guidance
brain development
peripheral nervous system development
myelination
cell-cell adhesion
protein localization to paranode region of axon
transmission of nerve impulse
paranodal junction assembly
heterotypic cell-cell adhesion
clustering of voltage-gated sodium channels
synapse organization
protein localization to juxtaparanode region of axon
protein targeting to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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