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Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Neurofibromin Fusion Protein Ag25799 (1-100 aa encoded by M60915) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.4 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MAAHRPVEW VQAVVSRFDE QLPIKTGQQN THTKVSTEHN KECLINISKY KFSLVISGLT TILKNVNNMR IFGEAAEKNL YLSQLIILDT LEKCLAGQPK D (1-100 aa encoded by M60915 )
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp686J1293; FLJ21220; Neurofibromatosis-related protein NF-1; Neurofibromin; Neurofibromin truncated
Gene Aliases: NF1; NFNS; VRNF; WSS
UniProt ID: (Human) P21359
Entrez Gene ID: (Human) 4763
Molecular Function:
GTPase-activating protein
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