Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bHLHa6; Class A basic helix-loop-helix protein 6; NeuroD3; Neurogenic basic-helix-loop-helix protein; neurogenic differentiation 3; Neurogenic differentiation factor 3; Neurogenin-1; NGN-1
Gene Aliases: AKA; BHLHA6; Math4C; NEUROD3; NEUROG1; NGN; NGN1
UniProt ID: (Human) Q92886
Entrez Gene ID: (Human) 4762