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Product Details
10440-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Neurogranin Fusion Protein Ag0676 (1-78 aa encoded by BC002835)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDCCTENAC SKPDDDILDI PLDDPGANAA AAKIQASFRG HMARKKIKSG ERGRKGPGPG GPGGAGVARG GAGGGPSGD (1-78 aa encoded by BC002835)
Target Information
Neurogranin is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calmodulin-binding protein; Neurogranin; neurogranin (protein kinase C substrate, RC3); Ng; postsynaptic spine 1; protein kinase C substrate; Protein kinase C substrate 7.5 kDa protein; RC3
Gene Aliases: 0710001B06Rik; AI838505; hng; NG; NG/RC3; NRGN; Pss1; R75334; RC3
UniProt ID: (Human) Q92686, (Mouse) P60761, (Rat) Q04940
Entrez Gene ID: (Human) 4900, (Mouse) 64011, (Rat) 64356
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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