This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase, regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-flanking peptide of NPY; CPON; Neuropeptide tyrosine; Neuropeptide Y; Neuropeptide-Y; NPY; OTTHUMP00000201947; prepro-neuropeptide Y; Pro-neuropeptide Y
Gene Aliases: 0710005A05Rik; NPY; PYY4