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Proteintech
Neuroserpin Polyclonal Antibody
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Product Details
12558-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Neuroserpin Fusion Protein Ag3275 (109-410 aa encoded by BC018043)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ANSLFVQNG FHVNEEFLQM MKKYFNAAVN HVDFSQNVAV ANYINKWVEN NTNNLVKDLV SPRDFDAATY LALINAVYFK GNWKSQFRPE NTRTFSFTKD DESEVQIPMM YQQGEFYYGE FSDGSNEAGG IYQVLEIPYE GDEISMMLVL SRQEVPLATL EPLVKAQLVE EWANSVKKQK VEVYLPRFTV EQEIDLKDVL KALGITEIFI KDANLTGLYD NKEIFLSKAI HKSFLEVNEE GSEAAAVSGM IAISRMAVLY PQVIVDHPFF FLIRNRRTGT ILFMGRVMHP ETMNTSGHDF EEL (109-410 aa encoded by BC018043)
Target Information
This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781N13156; Neuroserpin; Peptidase inhibitor 12; PI-12; protease inhibitor 17; serine (or cysteine) peptidase inhibitor, clade I, member 1; serine (or cysteine) proteinase inhibitor clade member 1; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; Serine protease inhibitor 17; Serpin I1; serpin peptidase inhibitor clade I member 1; serpin peptidase inhibitor, clade I (neuroserpin), member 1; serpin peptidase inhibitor, clade I, member 1
Gene Aliases: AI837402; neuroserpin; Ns; PI-12; PI12; raPIT5a; SERPINI1; Spi17
UniProt ID: (Human) Q99574, (Mouse) O35684, (Rat) Q9JLD2
Entrez Gene ID: (Human) 5274, (Mouse) 20713, (Rat) 116459
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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