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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 23 amino acid peptide from near the amino terminus of human neurotrypsin.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||2.5 µg/ml|
|Western Blot (WB)||0.5-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is SK-N-SH cell lysate.
PA5-20363 can be used with blocking peptide PEP-0483.
Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Brain-specific serine protease 3; BSSP-3; BSSP-3, BSSP3, MRT1; Leydin; Motopsin; Neurotrypsin; peptidase, serine, 12 (neurotrypsin, motopsin); protease, serine, 12 (neurotrypsin, motopsin); protease, serine, 12 neurotrypsin (motopsin); Serine protease 12
BSSP-3; BSSP3; motopsin; MRT1; Nt; PRSS12