Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
0.5-2 µg/mL | - |
Immunohistochemistry (IHC) |
5 µg/mL | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A 17 amino acid peptide from near the carboxy terminus of human Nicastrin. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID |
AB_11152451 |
A suggested positive control is mouse brain tissue lysate.
PA5-20303 can be used with blocking peptide PEP-0428.
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: anterior pharynx-defective 2; Nicastrin; OTTHUMP00000031840
Gene Aliases: 9430068N19Rik; AA727311; Aph2; ATAG1874; D1Dau13e; KIAA0253; mKIAA0253; NCSTN; Nct; UNQ1874/PRO4317
UniProt ID: (Human) Q92542, (Mouse) P57716, (Rat) Q8CH12
Entrez Gene ID: (Human) 23385, (Mouse) 59287, (Rat) 289231
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