Immunogen sequence: EPGLVMSSCL DEPATEFFGN TAEQTEQFLQ QNRTKQVEGV TRRHVLSDLE DDEVRDLGST GTSSVQRQEV KIEESEASVE GFSELENSEE TRTESWELKN
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
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Protein Aliases: Glycogen synthase kinase 3 beta-interacting protein; GSK3B-interacting protein; hNinein; Ninein; ninein (GSK3B interacting protein); ninein centrosomal protein
Gene Aliases: KIAA1565; NIN; SCKL7
UniProt ID: (Human) Q8N4C6
Entrez Gene ID: (Human) 51199