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Product Details
14772-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Noggin Fusion Protein Ag6586 (1-232 aa encoded by BC034027)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.13 mg/mL
Storage conditions
-20°C
Product Specific Information
Immunogen sequence: MERCPSLGV TLYALVVVLG LRATPAGGQH YLHIRPAPSD NLPLVDLIEH PDPIFDPKEK DLNETLLRSL LGGHYDPGFM ATSPPEDRPG GGGGAAGGAE DLAELDQLLR QRPSGAMPSE IKGLEFSEGL AQGKKQRLSK KLRRKLQMWL WSQTFCPVLY AWNDLGSRFW PRYVKVGSCF SKRSCSVPEG MVCKPSKSVH LTVLRWRCQR RGGQRCGWIP IQYPIISECK CSC (1-232 aa encoded by BC034027)
Target Information
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Noggin; Noggin precursor; symphalangism 1 (proximal)
Gene Aliases: NOG
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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