Invitrogen

Noggin Polyclonal Antibody

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Noggin Polyclonal Antibody

Product Details

PA5-95474

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

ELISA (ELISA)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human Noggin recombinant protein (Position: L43-T153).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.01mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807276

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human Hela whole cell, human MCF-7 whole cell, human HepG2 whole cell, human A375 whole cell, human 22RV1 whole cell. IHC: human placenta tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Noggin; Noggin precursor; symphalangism 1 (proximal)

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Gene Aliases: NOG; SYM1; SYNS1; SYNS1A

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UniProt ID: (Human) Q13253

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Entrez Gene ID: (Human) 9241

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Function(s)
protein binding cytokine binding protein complex binding protein homodimerization activity intercellular signal molecule
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation in utero embryonic development endoderm formation mesoderm formation epithelial to mesenchymal transition neural plate morphogenesis neural tube closure nervous system development motor neuron axon guidance dorsal/ventral pattern formation spinal cord development cell differentiation in hindbrain pituitary gland development negative regulation of cell migration BMP signaling pathway negative regulation of BMP signaling pathway somatic stem cell population maintenance wound healing middle ear morphogenesis embryonic digit morphogenesis regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter axial mesoderm development notochord morphogenesis embryonic skeletal system development negative regulation of astrocyte differentiation positive regulation of epithelial cell proliferation cartilage development negative regulation of cardiac muscle cell proliferation limb development embryonic skeletal joint morphogenesis negative regulation of cytokine activity face morphogenesis negative regulation of pathway-restricted SMAD protein phosphorylation lung morphogenesis prostatic bud formation ureteric bud formation fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of cartilage development somite development negative regulation of canonical Wnt signaling pathway positive regulation of branching involved in ureteric bud morphogenesis positive regulation of glomerulus development regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation negative regulation of apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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