NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS; blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.
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Protein Aliases: Foocen; Glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; KIAA0886; My043; Neurite outgrowth inhibitor; NI-220/250; NOGO; Nogo protein; Reticulon-4; RTN4; SP1507
Gene Aliases: NI-250; Nogo; Nogo-A; r; rat N; rat NogoA; Rtn4; Vp20
UniProt ID: (Rat) Q9JK11
Entrez Gene ID: (Rat) 83765
Molecular Function: membrane traffic protein