Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Nogo-B Recombinant Rabbit Monoclonal Antibody (JM02-34)

Advanced Verification
1 Published Figure
1 Reference
View all (5) Nogo-B antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Nogo-B Recombinant Rabbit Monoclonal Antibody (JM02-34)

Product Details

MA5-32763

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:1,000
-

Immunoprecipitation (IP)

1:10-1:50
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JM02-34

Immunogen

Synthetic peptide within Human Nogo aa 111-160.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2810040

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

Nogo-B is a member of the reticulon-4 (RTN4) family of proteins, primarily localized to the endoplasmic reticulum and expressed in many tissues, especially vascular endothelial and smooth muscle cells. It plays a key role in regulating vascular remodeling, cell migration, and tissue repair by influencing cytoskeletal organization and signaling pathways. Unlike Nogo-A, which is known for inhibiting nerve regeneration, Nogo-B is more involved in maintaining vascular homeostasis and modulating inflammatory responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ASY; Foocen; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; Nogo protein; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RTN4-C; NSP; reticulon; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4a; RTN4b; RTN4c; unnamed protein product

View more View less

Gene Aliases: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; KIAA0886; mKIAA0886; mKIAA4153; My043; Nbla00271; Nbla10545; NgA; NI220/250; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP; NSP-CL; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507

View more View less

UniProt ID: (Human) Q9NQC3, (Mouse) Q99P72

View more View less

Entrez Gene ID: (Human) 57142, (Mouse) 68585

View more View less

Function(s)
RNA binding protein binding ubiquitin protein ligase binding protein homodimerization activity cadherin binding metal ion binding protein complex binding poly(A) RNA binding
Process(es)
angiogenesis nervous system development axonogenesis axonal fasciculation negative regulation of neuron projection development cerebral cortex radial glia guided migration negative regulation of cell growth regulation of cell migration negative regulation of axon extension positive regulation of dopamine secretion negative regulation of neuron differentiation positive regulation of glial cell differentiation negative regulation of axonogenesis regulation of sensory perception of pain regulation of nervous system development cardiac epithelial to mesenchymal transition negative regulation of neuron projection regeneration endoplasmic reticulum tubular network organization regulation of branching morphogenesis of a nerve blastocyst formation leukocyte migration involved in inflammatory response apoptotic process endoplasmic reticulum organization brain development positive regulation of epithelial cell migration central nervous system vasculogenesis neuron differentiation positive regulation of mammary gland epithelial cell proliferation positive regulation of toll-like receptor 9 signaling pathway positive regulation of Rac protein signal transduction cell migration involved in vasculogenesis regulation of apoptotic process positive regulation of angiogenesis modulation of synaptic transmission protein stabilization nuclear pore complex assembly positive regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein localization to lysosome cellular response to hypoxia endoplasmic reticulum tubular network assembly cellular sphingolipid homeostasis cell adhesion involved in sprouting angiogenesis regulation of postsynapse assembly negative regulation of beta-amyloid formation positive regulation of neutrophil migration positive regulation of macrophage migration positive regulation of protein localization to endoplasmic reticulum positive regulation of ERBB3 signaling pathway positive regulation of artery morphogenesis endoplasmic reticulum tubular network membrane organization positive regulation of hepatocyte proliferation negative regulation of vasculogenesis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support