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Alomone Labs, LTD
Noradrenaline Transporter (NET) (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
Noradrenaline Transporter (NET) (extracellular) Antibody (AMT-002-200UL) in ICC/IF
Expression of Noradrenaline transporter (NET) in live intact rat PC12 cells - Cell surface detection of Noradrenaline transporter (NET) in live intact rat pheochromocytoma PC12 cells. Cells were stained with Anti-Noradrenaline Transporter (NET) (extracellular) Antibody (#AMT-002), (1:100), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). Cell nuclei (blue) were visualized using cell-per... View More
Product Details
AMT-002-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KLLNASVLGDHTKYSK, corresponding to amino acid residues 189-204 of mouse NET, 2nd extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Norepinephrine Transporter [NET, or noradrenaline transporter (NAT)] is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression. Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NaCl-dependent norepinephrine transporter; NE transporter; NET; neurotransmitter transporter, noradrenal; noradrenaline; Norepinephrine transporter; Sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; Solute carrier family 6 member 2; transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
Gene Aliases: NE-T; NET; Slc6a2; Slc6a5
UniProt ID: (Mouse) O55192
Entrez Gene ID: (Rat) 83511, (Mouse) 20538
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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