Immunogen sequence: MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD GDAQPRETWG KKIDFLLSVV; Positive Samples: A-549, SH-SY5Y, Mouse kidney, Mouse spinal cord; Cellular Location: Membrane, Multi-pass membrane protein
Norepinephrine Transporter [NET, or noradrenaline transporter (NAT)] is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression. Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD.
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Protein Aliases: NaCl-dependent norepinephrine transporter; NE transporter; NET; neurotransmitter transporter; neurotransmitter transporter, noradrenal; noradrenaline; Norepinephrine transporter; Sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter), member 2; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; Solute carrier family 6 member 2; solute carrier family 6 member 5; transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
Gene Aliases: NAT1; NE-T; NET; NET1; SLC6A2; SLC6A5
Molecular Function: primary active transporter