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          • Primary Antibodies ›
          • NOTCH1 Antibodies

          OriGene

          Notch1 Polyclonal Antibody

          View all (54) NOTCH1 antibodies

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          Cite Notch1 Polyclonal Antibody

          Additional Information:
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          Notch1 Polyclonal Antibody

          Product Details

          TA590258

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:5,000-1:20,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:250-1:2,000
          -

          ELISA (ELISA)

          1:100-1:2,000
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.9 mg/mL

          Purification

          Protein A/G

          Storage buffer

          PBS

          Contains

          no preservative

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Neurogenic locus notch homolog protein 1; Notch 1; Notch homolog 1, translocation-associated; NOTCH1; RP23-306D20.12; RP23-306D20.12-001; TAN1; Translocation-associated notch protein TAN-1; unnamed protein product

          View more View less

          Gene Aliases: AOS5; AOVD1; hN1; NOTCH1; TAN1

          View more View less

          UniProt ID: (Human) P46531

          View more View less

          Entrez Gene ID: (Human) 4851

          View more View less

          Function(s)
          chromatin binding transcription coactivator activity enzyme inhibitor activity transmembrane signaling receptor activity Notch binding calcium ion binding protein binding enzyme binding chromatin DNA binding signaling receptor activity identical protein binding metal ion binding transcription regulator activator activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter angiogenesis luteolysis in utero embryonic development epithelial to mesenchymal transition liver development heart looping sprouting angiogenesis positive regulation of neuroblast proliferation inhibition of neuroepithelial cell differentiation inflammatory response to antigenic stimulus outflow tract morphogenesis endocardium development endocardium morphogenesis atrioventricular node development coronary vein morphogenesis aortic valve morphogenesis atrioventricular valve morphogenesis coronary sinus valve morphogenesis pulmonary valve morphogenesis mitral valve formation endocardial cushion development epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac chamber formation cardiac ventricle morphogenesis cardiac atrium morphogenesis cardiac right atrium morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle formation ventricular trabecula myocardium morphogenesis growth involved in heart morphogenesis negative regulation of cell proliferation involved in heart valve morphogenesis regulation of cardioblast proliferation Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation cell migration involved in endocardial cushion formation negative regulation of extracellular matrix constituent secretion pericardium morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein import into nucleus apoptotic process immune response humoral immune response Notch signaling pathway positive regulation of transcription of Notch receptor target spermatogenesis determination of left/right symmetry compartment pattern specification axonogenesis axon guidance foregut morphogenesis endoderm development heart development cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation epidermis development regulation of Notch signaling pathway auditory receptor cell fate commitment epidermal cell fate specification glial cell differentiation gene expression regulation of gene expression negative regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion negative regulation of myotube differentiation mesenchymal cell development regulation of somitogenesis calcium ion regulated exocytosis cell differentiation in spinal cord neural tube development central nervous system neuron differentiation cell differentiation protein catabolic process neuron differentiation keratinocyte differentiation negative regulation of ossification lung development embryonic limb morphogenesis regulation of cell migration positive regulation of cell migration positive regulation of BMP signaling pathway negative regulation of BMP signaling pathway forebrain development hair follicle morphogenesis organ regeneration response to muramyl dipeptide response to lipopolysaccharide negative regulation of collagen biosynthetic process embryonic hindlimb morphogenesis tube formation skeletal muscle cell differentiation cellular response to vascular endothelial growth factor stimulus regulation of cell proliferation tissue regeneration retinal cone cell differentiation positive regulation of apoptotic process negative regulation of programmed cell death negative regulation of catalytic activity positive regulation of viral genome replication positive regulation of endothelial cell differentiation regulation of auditory receptor cell differentiation negative regulation of auditory receptor cell differentiation positive regulation of keratinocyte differentiation negative regulation of myoblast differentiation negative regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of glial cell differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of calcium ion-dependent exocytosis positive regulation of JAK-STAT cascade negative regulation of photoreceptor cell differentiation positive regulation of Ras protein signal transduction somatic stem cell division neuron fate commitment astrocyte differentiation oligodendrocyte differentiation positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation branching morphogenesis of an epithelial tube venous blood vessel morphogenesis homeostasis of number of cells within a tissue epithelial cell proliferation regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation regulation of neurogenesis negative regulation of neurogenesis regulation of developmental process positive regulation of smooth muscle cell differentiation cardiac muscle tissue morphogenesis cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation negative regulation of glial cell proliferation cilium morphogenesis cardiac epithelial to mesenchymal transition negative regulation of cell adhesion molecule production cardiac muscle cell myoblast differentiation cardiac septum morphogenesis ventricular septum morphogenesis secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development prostate gland epithelium morphogenesis regulation of epithelial cell proliferation involved in prostate gland development arterial endothelial cell differentiation venous endothelial cell differentiation cardiac vascular smooth muscle cell development endocardial cell differentiation vasculogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis neuroendocrine cell differentiation regulation of cell adhesion involved in heart morphogenesis heart trabecula morphogenesis positive regulation of cardiac epithelial to mesenchymal transition negative regulation of biomineral tissue development positive regulation of ERK1 and ERK2 cascade left/right axis specification cellular response to tumor cell cellular response to follicle-stimulating hormone stimulus cellular response to hypoxia distal tubule development collecting duct development regulation of stem cell proliferation glomerular mesangial cell development epithelial cell fate commitment T-helper 17 type immune response negative regulation of cell migration involved in sprouting angiogenesis negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance interleukin-17-mediated signaling pathway chemical synaptic transmission, postsynaptic negative regulation of cold-induced thermogenesis regulation of extracellular matrix assembly apoptotic process involved in embryonic digit morphogenesis positive regulation of apoptotic process involved in morphogenesis positive regulation of aorta morphogenesis negative regulation of cell-cell adhesion mediated by cadherin negative regulation of stem cell differentiation negative regulation of anoikis negative regulation of pro-B cell differentiation negative regulation of endothelial cell chemotaxis
          It has to be done as per old AB suggested Products section.

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