The antibody detects endogenous levels of total NPR2 protein.
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
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Protein Aliases: AMDM; ANP-B; ANPb; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase 2B; Guanylate cyclase B; guanylyl cyclase-B; GUC2B; GUCY2B; natriuretic peptide receptor B type; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); Nppb receptor; NPR-B; NPRB; NPRBi
Gene Aliases: AMDM; ANPb; ANPRB; cn; ECDM; GC-B; GC-B2; GC-B3; GUC2B; GUCY2B; mNPR-B; NPR2; NPRB; NPRBi; pwe; SNSK