Keep as concentrated solution.
Positive Control: HepG2, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
TCEB1 is known as protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Western blots using two different antibodies (P100962-T200 and P100963_P050/P100963_P100) against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HPR1 antibody; hTREX84; hTREX84 antibody; Nuclear matrix protein p84; nuclear matrix protein p84 antibody; P84 antibody; p84N5; P84N5 antibody; THO complex 1 antibody; THO complex subunit 1; THO complex subunit 1 antibody; Tho1; tho1 antibody; THOC1 antibody
Gene Aliases: 3110002N20Rik; AW107452; HPR1; LRRGT00070; NMP-84; P84; P84N5; THOC1
Molecular Function: nucleic acid binding