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Invitrogen
OAS1 Polyclonal Antibody
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Product Details
PA5-115682
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human OAS1(Accession P00973), corresponding to amino acid residues Y329-R379.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total OAS1.
Target Information
OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1; (2-5')oligo(A) synthetase 1A; 2',5'-oligo A synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1G; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthetase 1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthase 1A; 2-5A synthetase 1; 2-5A synthetase 1A; 25 oligoadenylate synthetase; E16 (2'-5') oligo A synthetase; E18/E16; IFI 4; IFI4; OAS 1; p42 OAS; p46/p42 OAS
Gene Aliases: E18/E16; IFI-4; L3; OAS1; Oas1a; Oas1g; OIAS; Oias1; OIASI
UniProt ID: (Human) P00973, (Rat) Q05961, (Mouse) P11928
Entrez Gene ID: (Human) 4938, (Rat) 192281, (Mouse) 246730
glucose metabolic process
response to virus
glucose homeostasis
negative regulation of viral genome replication
defense response to virus
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
purine nucleotide biosynthetic process
immune response
metabolic process
cellular response to interferon-alpha
innate immune response
negative regulation of viral process
protein oligomerization
regulation of ribonuclease activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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