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|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human OAS1|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Inhibition of 2',5'-oligoadenylate synthetase expression and function by the human cytomegalovirus ORF94 gene product.
PA5-13209 was used in western blot to identify the function of ORF94 in human cytomegalovirus
|Tan JC,Avdic S,Cao JZ,Mocarski ES,White KL,Abendroth A,Slobedman B||Journal of virology (85:5696)||2011|
(2-5')oligo(A) synthase 1; (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1A; (2-5)oligo(A) synthetase 1; 2',5'-oligo A synthetase 1; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5-oligoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthase 1A; 2-5A synthetase 1; 2-5A synthetase 1A; E16 (2'-5') oligo A synthetase; p42 OAS
E18/E16; IFI-4; L3; OAS1; Oas1a; OIAS; Oias1; OIASI