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Invitrogen
OAS1 Polyclonal Antibody
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Product Details
PA5-41755
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human OAS1 (aa 1-50).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: MMDLRNTPAK SLDKFIEDYL LPDTCFRMQI NHAIDIICGF LKERCFRGSS
Sequence homology: Cow: 86%; Dog: 79%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 79%; Rabbit: 79%; Rat: 79%
Target Information
OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (2-5')oligo(A) synthase 1; 2',5'-oligo A synthetase 1; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1 isoform p42; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthetase 1; E16 (2'-5') oligo A synthetase; E18/E16; IFI 4; IFI4; OAS 1; p46/p42 OAS; short exon 3; targeted by nonsense-mediated decay (NMD) due to premature termination codon in exon 4; unnamed protein product
Gene Aliases: E18/E16; IFI-4; IMD100; OAS1; OIAS; OIASI
UniProt ID: (Human) P00973
Entrez Gene ID: (Human) 4938
immune system process
glucose metabolic process
response to virus
positive regulation of interferon-beta production
positive regulation of tumor necrosis factor production
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
cellular response to interferon-alpha
cellular response to interferon-beta
glucose homeostasis
defense response to bacterium
surfactant homeostasis
negative regulation of viral genome replication
innate immune response
protein oligomerization
defense response to virus
type I interferon signaling pathway
negative regulation of type I interferon-mediated signaling pathway
regulation of ribonuclease activity
interleukin-27-mediated signaling pathway
cellular response to exogenous dsRNA
positive regulation of monocyte chemotactic protein-1 production
negative regulation of IP-10 production
defense response to other organism
cellular response to virus
antiviral innate immune response
positive regulation of cellular respiration
negative regulation of chemokine (C-X-C motif) ligand 2 production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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