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Product Details
PA5-115683
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human OAS2(Accession P29728), corresponding to amino acid residues T619-F669.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900318
Product Specific Information
Antibody detects endogenous levels of total OAS2.
Target Information
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates. These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (2'-5')oligo(A) synthetase 2; (2-5')oligo(A) synthase 2; 2',5'-oligoadenylate synthetase-like 11; 2'-5' oligoadenylate synthetase-like 11; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2,5-oligoadenylate synthetase-like 11; 2-5A synthase 2; A synthetase 2; MGC78578; p69 OAS / p71 OAS; p69OAS / p71OAS
Gene Aliases: OAS2; Oasl11
UniProt ID: (Human) P29728, (Mouse) E9Q9A9
Entrez Gene ID: (Human) 4939, (Mouse) 246728
nucleobase-containing compound metabolic process
RNA catabolic process
protein glycosylation
response to virus
protein myristoylation
defense response to virus
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
immune system process
purine nucleotide biosynthetic process
immune response
innate immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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