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Western blot of OAS2 in (A) Daudi (B) Jurkat and (C) K562 lysates was performed using 35ug protein in RIPA buffer. Lysates were probed with an OAS2 polyclonal antibody (Product# PA5-37879) at a dilution of 0.3ug/ml and incubated for 1 hour, followed by chemiluminescent detection.
|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Peptide with sequence QPNKCFLEQIDSAVN, from the internal region of OAS2 (aa357-371)|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.3-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates. These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
(2'-5')oligo(A) synthetase 2; 2'-5'-oligoadenylate synthetase 2 69/71kDa; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2'-5'oligo; 2-5A synthase 2; A synthetase 2; p69 OAS / p71 OAS