This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: TLVLFFSDLKQ FQDQKRSQRD ILDKTGDKLK FCLFTKWLKN NFEIQKSLDG FTIQVFTKNQ RISFEVLAAF NALSLNDNPS PWIYRELKRS LDKTNASPGE FAVCFTELQQ K
Highest antigen sequence identity to the following orthologs - mouse 42%, rat 44%.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates. These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: (2'-5')oligo(A) synthetase 2; (2-5')oligo(A) synthase 2; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2; A synthetase 2; MGC78578; p69 OAS / p71 OAS; p69OAS / p71OAS
Gene Aliases: OAS2
UniProt ID: (Human) P29728
Entrez Gene ID: (Human) 4939
Molecular Function: nucleotidyltransferase