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Invitrogen
OASL Polyclonal Antibody
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FIGURE: 1 / 2
OASL Antibody (PA5-31317) in WB
Western blot analysis of OASL was performed by loading 100 ng of recombinant OASL protein (lane 1) cell lysates in RIPA Lysis and Extraction buffer (Product # 89900) and Page Ruler Plus Protein Ladder (Product # 26619) onto a 30% Acrylamide/Bis gel. Proteins were transferred and membrane was blocked in 5% milk for one hour at room temperature. OASL was detected at approximately 59 kDa using an OASL polyclonal antibody (Product # PA5-31317) at a dilution of 1:1000 in 5% milk overnight at at 4°C on a rocking platform, followed by a goat anti... View More
Product Details
PA5-31317
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human OASL. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: HeLa, HepG2, HCT116.
Predicted reactivity: Chimpanzee (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; p59 OASL; p59OASL; Thyroid receptor-interacting protein 14; TR-interacting protein 14; unnamed protein product
Gene Aliases: OASL; OASL1; OASLd; p59 OASL; p59-OASL; p59OASL; TRIP-14; TRIP14
UniProt ID: (Human) Q15646
Entrez Gene ID: (Human) 8638
immune system process
response to virus
negative regulation of viral genome replication
innate immune response
defense response to virus
type I interferon signaling pathway
interleukin-27-mediated signaling pathway
defense response to other organism
antiviral innate immune response
positive regulation of RIG-I signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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