Immunogen sequence: FLPNTLPKEGL ETNADIIKNE NEDKQKEEVK KEKYGITKDF LPFMKSLSCN
Highest antigen sequence identity to the following orthologs - mouse 65%, rat 63%.
The organic anion transporting polypeptides, OATP-A (also designated OATP1, OATP1A2 and SLC21A3) and OATP-C (also designated OATP2, SLC21A6 and LST1), mediate hepatic uptake of cardiac glycosides. The expression of OATP-C, but not OATP-A, is inducible by phenobarbital and pregnenolone-16a-carbonitrile, resulting in the increased capacity of the liver to extract cardiac glycosides from the plasma. OATP-A is expressed in liver and kidney and helps mediate sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate, estradiol-17-glucuronide and prostaglandin. OATP-C is exclusively expressed in liver and is localized to the basolateral hepatocyte membrane.
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Protein Aliases: OATP; OATP-1; OATP-A; OATP1A2; organic anion transporting polypeptide A; Organic anion-transporting polypeptide 1; SLC21A3; SLCO1A2; SO1A2; Sodium-independent organic anion transporter; solute carrier family 21 (organic anion transporter), member 3; Solute carrier family 21 member 3; Solute carrier organic anion transporter family member 1A2; solute carrier organic anion transporter family, member 1A2
Gene Aliases: OATP; OATP-A; OATP1; OATP1A2; SLC21A3; SLCO1A2
UniProt ID: (Human) P46721
Entrez Gene ID: (Human) 6579
Molecular Function: transporter