This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants.
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Protein Aliases: BBB-specific anion transporter type 1; blood-brain barrier specific anion transporter; Blood-brain barrier-specific anion transporter 1; OAT-RP-5; OATP-14; OATP-F; OATP2; Organic anion transporter 2; Organic anion transporter F; Organic anion transporter polypeptide-related protein 5; organic anion transporting polypeptide 14; Organic anion-transporting polypeptide 14; solute carrier family 21 (organic anion transporter), member 14; Solute carrier family 21 member 14; Solute carrier organic anion transporter family member 1C1; solute carrier organic anion transporter family, member 1C1; Thyroxine transporter
Gene Aliases: Bsat1; OATP-14; OATP-F; OATP1; OATP14; OATP1C1; Oatp2; OATPF; OATPRP5; SLC21A14; SLCO1C1
Molecular Function: transporter