Immunogen sequence: QSRLTDAKRI NWRTVLSGGS LYIEIPGGAL PEGSKDSFAV LLEFAEEQLR ADHVFICFHK NREDRAALLR TFSFLGFEIV RPGHPLVPKR PDACFMAYTF ERESSGEEEE
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 81%.
OAZ1 catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. This protein play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein expression is auto-regulated by polyamine-enhanced translational frameshifting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antizyme 1; AZ1; OAZ; ODC-Az; Ornithine decarboxylase antizyme 1
Gene Aliases: AZI; OAZ; OAZ1
UniProt ID: (Human) P54368
Entrez Gene ID: (Human) 4946
Molecular Function: enzyme modulator