Immunogen sequence: PHPLSKIPGG RGGGRDPSLS ALIYKDEKLT VTQDLPVNDG KPHIVHFQYE VTEVKVSSWD
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 98%.
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.
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Protein Aliases: AZ2; ODC-Az 2; Ornithine decarboxylase antizyme 2
Gene Aliases: AZ2; OAZ2
UniProt ID: (Human) O95190
Entrez Gene ID: (Human) 4947
Molecular Function: enzyme modulator