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Proteintech
OCRL Polyclonal Antibody
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Product Details
17695-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
OCRL Fusion Protein Ag11900 (538-893 aa encoded by BC094726)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is specific to OCRL.
Immunogen sequence: VDERRYRKV FEDSVRIMDR MENDFLPSLE LSRREFVFEN VKFRQLQKEK FQISNNGQVP CHFSFIPKLN DSQYCKPWLR AEPFEGYLEP NETVDISLDV YVSKDSVTIL NSGEDKIEDI LVLHLDRGKD YFLTISGNYL PSCFGTSLEA LCRMKRPIRE VPVTKLIDLE KSLLQMVPLD EGASERPLQV PKEIWLLVDH LFKYACHQED LFQTPGMQEE LQQIIDCLDT SIPETIPGSN HSVAEALLIF LEALPEPVIC YELYQRCLDS AYDPRICRQV ISQLPRCHRN VFRYLMAFLR ELLKFSEYNS VNANMIATLF TSLLLRPPPN LMARQTPSDR QRAIQFLLGF LLGSEED (538-893 aa encoded by BC094726 )
Target Information
The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. OCRL1 is a type II 5-phosphatase that is mutated in the oculocerebrorenal syndrome of Lowe (OCRL). OCRL is a rare X-linked disorder that is characterized in part by congenital cataracts, mental retardation, muscular hypotonia and renal tubular dysfunction. OCRL1 has a high affinity for phosphatidylinositol 4,5-bisphosphate as well as inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate as substrates. OCRL1 is localized to the Golgi complex and is thought to be part of the trans-Golgi network (TGN), which suggests that OCRL1 plays a role in protein sorting and trafficking within the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Inositol polyphosphate 5-phosphatase OCRL; Inositol polyphosphate 5-phosphatase OCRL-1; Lowe oculocerebrorenal syndrome protein; OCRL-1; oculocerebrorenal syndrome of Lowe; Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase
Gene Aliases: 9530014D17Rik; BB143339; INPP5F; LOCR; NPHL2; OCRL; OCRL-1; OCRL1
UniProt ID: (Human) Q01968, (Mouse) Q6NVF0
Entrez Gene ID: (Human) 4952, (Rat) 317576, (Mouse) 320634
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GTPase activator activity
protein binding
Rac GTPase binding
inositol-1,4,5-trisphosphate 5-phosphatase activity
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol phosphate phosphatase activity
molecular_function
hydrolase activity
phosphatase
in utero embryonic development
lipid metabolic process
phosphatidylinositol biosynthetic process
signal transduction
cilium assembly
regulation of GTPase activity
positive regulation of GTPase activity
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
regulation of small GTPase mediated signal transduction
biological_process
cell projection organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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