Recommended positive controls: 293T, A431, HeLa, HepG2.
Predicted reactivity: Mouse (89%), Rat (94%), Xenopus laevis (81%), Pig (97%), Chicken (94%), Chimpanzee (99%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
OCT1 (POU2F1) is a ubiquitously expressed transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. It modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NF-A1; Oct-1; Octamer-binding protein 1; Octamer-binding transcription factor 1; Octamer-binding transcription factor-1; OTF-1; POU domain, class 2, transcription factor 1
Gene Aliases: Oct-1; oct-1B; OCT1; Otf-1; OTF1; POU2F1