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Proteintech
OCTN2 Polyclonal Antibody
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Product Details
16331-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
OCTN2 Fusion Protein Ag9450 (1-142 aa encoded by BC012325)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MRDYDEVTA FLGEWGPFQR LIFFLLSASI IPNGFTGLSS VFLIATPEHR CRVPDAANLS SAWRNHTVPL RLRDGREVPH SCRRYRLATI ANFSALGLEP GRDVDLGQLE QESCPDGWEF SQDVYLSTIV TEWNLVCEDD WKA (1-142 aa encoded by BC012325)
Target Information
Carnitine (b-hydroxy-g-trimethylaminobutyrate) is a small, highly polar compound that aids in the b-oxidation of long-chain fatty acids. Organic cation/carnitine transporters (OCTN) assist in the elimination of cationic compounds, including xenobiotics, and transport carnitine for reabsorption in the kidney. Similar to organic cation transporters (OCT), OCTN proteins localize to the plasma membrane of epithelial cells. OCTN1 is expressed in kidney, trachea, bone marrow and fetal liver. OCTN2 is abundantly expressed in kidney, skeletal muscle, placenta and heart. OCTN3 is strongly expressed in testis and weakly expressed in kidney. The gene encoding human OCTN1 maps to chromosome 5 and the gene encoding human OCTN2 maps to chromosome 5q31. Mutations in the gene encoding OCTN2 leads to systemic carnitine deficiency (SCD), an autosomal recessive disorder characterized by cardiomyopathy, skeletal myopathy, lethargy, hypoglycemia and hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CT1; high-affinity carnitine transporter; high-affinity sodium dependent carnitine cotransporter; High-affinity sodium-dependent carnitine cotransporter; integral membrane transport protein; juvenile visceral steatosis; OCTN2VT; Organic cation/carnitine transporter 2; S22A5; solute carrier family 22 (organic cation transporter), member 5; Solute carrier family 22 member 5; solute carrier family 22, member 5; UST2r
Gene Aliases: CDSP; CT1; jvs; Lstpl; OCTN2; SLC22A5; UST2r
UniProt ID: (Human) O76082, (Mouse) Q9Z0E8, (Rat) O70594
Entrez Gene ID: (Human) 6584, (Mouse) 20520, (Rat) 29726
protein binding
ATP binding
carnitine transmembrane transporter activity
drug transmembrane transporter activity
symporter activity
cation:cation antiporter activity
quaternary ammonium group transmembrane transporter activity
PDZ domain binding
nucleotide binding
transporter activity
ion transmembrane transporter activity
transmembrane transporter activity
antibiotic transporter activity
secondary carrier transporter
sodium ion transport
drug transmembrane transport
carnitine metabolic process
quaternary ammonium group transport
carnitine transport
drug transport
quorum sensing involved in interaction with host
positive regulation of intestinal epithelial structure maintenance
sodium-dependent organic cation transport
cation transmembrane transport
carnitine transmembrane transport
transport
ion transport
mitochondrion organization
adult heart development
locomotory behavior
organic cation transport
ion transmembrane transport
antibiotic transport
reproductive structure development
transmembrane transport
modified amino acid transport
amino acid transmembrane transport
triglyceride metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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