Immunogen sequence: EPENNQMAIS NNSQQSNEQT DPEPEENETK KESSVPMCQG ELRHWKTGHY TLIHDHSKAE FALDLILYCG CEGWEPEYGG FTSYIAKGED EELLTVNPES NSLALVYRDR ETLKFVKHIN HRSLEQKKTF PNRTGFWDFS F
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 81%.
OGFOD1, a member of the 2-OG-Fe(II) dioxygenase family, plays an important role in ischemic survival and stress. It is an oxidoreductase containing a Prolyl 4-hydroxylase alpha subunit. An OGFOD1 iron binding residue is required for ATPAF1 gene expression. As a novel stress granule component, OGFOD1 plays important proapoptotic roles in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2-oxoglutarate and iron-dependent oxygenase domain containing 1; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; Prolyl 3-hydroxylase OGFOD1; Termination and polyadenylation 1 homolog; TPA1, termination and polyadenylation 1, homolog; uS12 prolyl 3-hydroxylase
Gene Aliases: 4930415J21Rik; AA387199; AA939912; AW061076; KIAA1612; mKIAA1612; OGFOD1; RGD1308848; TPA1
Molecular Function: chromatin/chromatin-binding, or -regulatory protein histone modifying enzyme