Immunogen sequence: TALTEPLEVE HVVGQGVLHR GGQLHGARPL GTGERWNLVV WLRASAVRNS LCPMCCREPD LVDDEGFGDG FTREEPATVD VCA
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 88%.
OGFOD2 is a member of the 2-OG-Fe(II) dioxygenase family which plays an important role in ischemic survival and stress. Like the related protein OGFOD1, OGFOD2 is an oxidoreductase containing a Prolyl 4-hydroxylase alpha subunit. Little is known about the function of OGFOD2, but its similarity to OGFOD1 suggests that it is a novel stress granule component that may play an important proapoptotic role in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2-oxoglutarate and iron-dependent oxygenase domain containing 2; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2
Gene Aliases: OGFOD2
UniProt ID: (Human) Q6N063
Entrez Gene ID: (Human) 79676