Immunogen sequence: MDDPDCDSTW EEDEEDAEDA EDEDCEDGEA AGARDADAGD EDEESEEPRA ARPSSFQSRM TGSRNWRATR DMCRYRHNYP DLVERDCNGD TPNLSFYRNE IRFLPNGCFI EDILQNWTDN YDLLEDNHSY IQWLFPLREP GVNWHAKPLT LREVEVFKSS QEIQERLVRA YELMLGFYGI RLEDRGTGTV GRAQNYQKRF QNLNWRSHNN LRITRILKSL GELGLEHFQA PLVRFFLEET LVRRELPGVR QSALDYFMFA VRCRHQRRQL VHFAWEHFRP; Positive Samples: A-431, Mouse kidney; Cellular Location: Cytoplasm, Nucleus
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
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Protein Aliases: OGFr; Opioid growth factor receptor; Protein 7-60; Zeta-type opioid receptor
Gene Aliases: 2010013E17Rik; OGFR
Molecular Function: receptor