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OGG1 Polyclonal Antibody
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Product Details
BS-3687R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human OGG1/8 hydroxyguanine DNA glycosylase, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
8-hydroxyguanine, a form of oxidative DNA damage induced by free radicals, causes G:C to T:A transversion. In E. Coli, three DNA repair enzymes exist to prevent the mutagenic effects of 8-hydroxyguanine. One of these enzymes, MutM, was found to have a functional yeast (yOgg1) and human (hOgg1) homologue. hOgg1 proteins efficiently released the 8-hydroxyguanine opposite the pyrimidine from DNA and cleaved the AP site in a manner similar to bacterial and yeast enzymes. Genetic backgrounds in control of the repair of damaged DNA are involved in the susceptibility to cancer development. The hOgg1 gene has been mapped to region 3p26. 2, a region showing loss of heterozygosity (LOH) in a variety of cancers. In particular, 3p25-p26 is a common LOH region in lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 8-hydroxyguanine DNA glycosylase; 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; AP lyase; DNA-apurinic or apyrimidinic site lyase; hOGG1; N-glycosylase/DNA lyase; OGG1 type 1f; unnamed protein product; yeast ogg1 homolog
Gene Aliases: HMMH; HOGG1; MMH; MUTM; OGG1; OGH1
UniProt ID: (Human) O15527, (Mouse) O08760, (Rat) O70249
Entrez Gene ID: (Human) 4968, (Mouse) 18294, (Rat) 81528
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
damaged DNA binding
catalytic activity
endonuclease activity
protein binding
microtubule binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
lyase activity
enzyme binding
oxidized purine DNA binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
purine-specific mismatch base pair DNA N-glycosylase activity
oxidized base lesion DNA N-glycosylase activity
DNA-(apurinic or apyrimidinic site) lyase activity
uracil DNA N-glycosylase activity
single-strand selective uracil DNA N-glycosylase activity
DNA N-glycosylase activity
DNA-3-methylbase glycosylase activity
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
DNA metabolism protein
DNA repair
base-excision repair
base-excision repair, AP site formation
nucleotide-excision repair
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
response to oxidative stress
response to radiation
cellular response to reactive oxygen species
hypomethylation of CpG island
depurination
depyrimidination
positive regulation of transcription from RNA polymerase II promoter
negative regulation of double-strand break repair via single-strand annealing
aging
metabolic process
response to estradiol
regulation of protein import into nucleus, translocation
nucleotide-excision repair, DNA incision
negative regulation of apoptotic process
nucleic acid phosphodiester bond hydrolysis
DNA catabolic process, endonucleolytic
acute inflammatory response
response to light stimulus
response to drug
response to ethanol
response to folic acid
cellular response to cadmium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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