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Invitrogen
OGT Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-83155
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human OGT. Recombinant protein control fragment (Product #RP-104617).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YCNLAHCLQI VCDWTDYDER MKKLVSIVAD QLEKNRLPSV HPHHSMLYPL SHGFRKAIAE RHGNLCLDKI NVLHKPPYEH PKDLKLSDGR L
Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ23071; MGC22921; o-glcnac transferase; O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase; unnamed protein product; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
Gene Aliases: HINCUT-1; HRNT1; MRX106; O-GLCNAC; OGT1; XLID106
UniProt ID: (Human) O15294
Entrez Gene ID: (Human) 8473
negative regulation of transcription from RNA polymerase II promoter
mitophagy
positive regulation of transcription from RNA polymerase II promoter by glucose
regulation of glycolytic process
regulation of gluconeogenesis
regulation of transcription from RNA polymerase II promoter
protein O-linked glycosylation
apoptotic process
signal transduction
response to nutrient
protein processing
hemopoiesis
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of protein ubiquitination
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
response to insulin
circadian regulation of gene expression
regulation of Rac protein signal transduction
positive regulation of translation
positive regulation of proteolysis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin receptor signaling pathway
regulation of synapse assembly
regulation of necroptotic process
cellular response to glucose stimulus
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of cold-induced thermogenesis
negative regulation of non-canonical inflammasome complex assembly
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
positive regulation of TORC1 signaling
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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