Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
OGT Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
PA5-83155
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human OGT. Recombinant protein control fragment (Product #RP-104617).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: YCNLAHCLQI VCDWTDYDER MKKLVSIVAD QLEKNRLPSV HPHHSMLYPL SHGFRKAIAE RHGNLCLDKI NVLHKPPYEH PKDLKLSDGR L
Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.
Target Information
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FLJ23071; MGC22921; o-glcnac transferase; O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
Gene Aliases: HINCUT-1; HRNT1; O-GLCNAC; OGT
UniProt ID: (Human) O15294
Entrez Gene ID: (Human) 8473
protein binding
phosphatidylinositol-3,4,5-trisphosphate binding
enzyme activator activity
transcription factor binding
acetylglucosaminyltransferase activity
protein N-acetylglucosaminyltransferase activity
protein domain specific binding
peptide binding
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K16 specific)
monosaccharide binding
protein O-GlcNAc transferase activity
protein modifying enzyme
positive regulation of protein phosphorylation
glucosamine metabolic process
regulation of glycolytic process
protein O-linked glycosylation
apoptotic process
signal transduction
response to nutrient
negative regulation of peptidyl-threonine phosphorylation
positive regulation of granulocyte differentiation
forebrain development
negative regulation of protein ubiquitination
response to insulin
cellular response to insulin stimulus
circadian regulation of gene expression
negative regulation of peptidyl-serine phosphorylation
regulation of Rac protein signal transduction
positive regulation of catalytic activity
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
positive regulation of cell size
positive regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin receptor signaling pathway
phosphatidylinositol-mediated signaling
intracellular distribution of mitochondria
positive regulation of histone H3-K4 methylation
negative regulation of cell death
positive regulation of histone H3-K27 methylation
protein homotrimerization
protein heterotrimerization
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to glucose stimulus
histone H3-K4 trimethylation
negative regulation of protein targeting to membrane
regulation of gluconeogenesis involved in cellular glucose homeostasis
cellular response to toxic substance
negative regulation of cellular response to hypoxia
positive regulation of protein localization to nucleus
positive regulation of reactive oxygen species biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support