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Fabgennix
OGT1 Polyclonal Antibody, FITC
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Product Details
OGT1-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 980-1030 on human O-linked N-acetylglucosamine transferase protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ23071; MGC22921; O linked N-acetylglucosamine transferase; o-glcnac transferase; O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
Gene Aliases: 1110038P24Rik; 4831420N21Rik; AI115525; HINCUT-1; HRNT1; O-GLCNAC; OGT; Ogtl
UniProt ID: (Human) O15294, (Mouse) Q8CGY8, (Rat) P56558
Entrez Gene ID: (Human) 8473, (Mouse) 108155, (Rat) 26295
protein binding
phosphatidylinositol-3,4,5-trisphosphate binding
enzyme activator activity
transcription factor binding
acetylglucosaminyltransferase activity
protein N-acetylglucosaminyltransferase activity
protein domain specific binding
peptide binding
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K16 specific)
monosaccharide binding
protein O-GlcNAc transferase activity
catalytic activity
N-acetyltransferase activity
lipid binding
transferase activity
transferase activity, transferring glycosyl groups
protein modifying enzyme
positive regulation of protein phosphorylation
glucosamine metabolic process
regulation of glycolytic process
protein O-linked glycosylation
apoptotic process
signal transduction
response to nutrient
negative regulation of peptidyl-threonine phosphorylation
positive regulation of granulocyte differentiation
forebrain development
negative regulation of protein ubiquitination
response to insulin
cellular response to insulin stimulus
circadian regulation of gene expression
negative regulation of peptidyl-serine phosphorylation
regulation of Rac protein signal transduction
positive regulation of catalytic activity
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
positive regulation of cell size
positive regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin receptor signaling pathway
phosphatidylinositol-mediated signaling
intracellular distribution of mitochondria
positive regulation of histone H3-K4 methylation
negative regulation of cell death
positive regulation of histone H3-K27 methylation
protein homotrimerization
protein heterotrimerization
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to glucose stimulus
histone H3-K4 trimethylation
negative regulation of protein targeting to membrane
regulation of gluconeogenesis involved in cellular glucose homeostasis
cellular response to toxic substance
negative regulation of cellular response to hypoxia
positive regulation of protein localization to nucleus
positive regulation of reactive oxygen species biosynthetic process
negative regulation of protein phosphorylation
positive regulation of gene expression
chromatin modification
rhythmic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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