Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization.
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Protein Aliases: neuronal olfactomedin related ER localized protein 2; NOE2; Noelin 2; Noelin-2; NOELIN2; NOELIN2_V1; olfactomedin 2; Olfactomedin-2; OlfC; OLFM2
Gene Aliases: A030009A06Rik; NOE2; NOELIN2; NOELIN2_V1; OlfC; OLFM2