The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers for astrocytes, oligodendrocytes, or their progenitors. Studies of central nervous system tumorigenesis suggests that novel molecular markers might be found among factors that have roles in glial development. Oligodendrocyte lineage genes (Olig 1 and 2) encode basic helix–loop–helix transcription factors. Human Olig genes are expressed strongly in oligodendroglioma, contrasting absent or low expression in astrocytoma. Therefore, there is diagnostic potential of Olig markers to augment identification of oligodendroglial tumors.
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Protein Aliases: basic domain, helix-loop-helix protein, class B, 1; Basic helix-loop-helix protein class B 1 antibody; bHLHb1; bHLHe19; Class B basic helix-loop-helix protein 1; Class E basic helix-loop-helix protein 19; human protein kinase C-binding protein RACK17; Oligo2; Oligo2 antibody; Oligodendrocyte transcription factor 2; Oligodendrocyte transcription factor 2 antibody; oligodendrocyte-specific bHLH transcription factor 2; Protein kinase C-binding protein; Protein kinase C-binding protein 2; Protein kinase C-binding protein RACK17
Gene Aliases: AI604895; BHLHB1; BHLHE19; Olg-2; OLIG2; OLIGO2; PRKCBP2; RACK17; RK17