Proteintech

OLR1 Polyclonal Antibody

Product Image Gallery

OLR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human heart tissue slide using 11837-1-AP ( OLR1 Antibody) at dilution of 1:200 (under 40x lens).

OLR1 Antibody in Western Blot (WB) — Human liver tissue were subjected to SDS PAGE followed by western blot with 11837-1-AP (OLR1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

OLR1 Antibody in Flow Cytometry (Flow) — 1X10^6 HUVEC cells were stained with 0.2ug OLR1 antibody (11837-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1500.

OLR1 Antibody in Immunoprecipitation (IP) — IP result of anti-OLR1 (IP:11837-1-AP, 4ug; Detection:11837-1-AP 1:800) with L02 cells lysate 1800ug.

Product Details

11837-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 5 publications 5 publications
Immunohistochemistry (IHC)	-	View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-
Flow Cytometry (Flow)	0.2 µg/1x10^6 cells	-
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	OLR1 Fusion Protein Ag2437 (1-273 aa encoded by BC022295) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.46 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MTFDDLKIQ TVKDQPDEKS NGKKAKGLQF LYSPWWCLAA ATLGVLCLGL VVTIMVLGMQ LSQVSDLLTQ EQANLTHQKK KLEGQISARQ QAEEASQESE NELKEMIETL ARKLNEKSKE QMELHHQNLN LQETLKRVAN CSAPCPQDWI WHGENCYLFS SGSFNWEKSQ EKCLSLDAKL LKINSTADLD FIQQAISYSS FPFWMGLSRR NPSYPWLWED GSPLMPHLFR VRGAVSQTYP SGTCAYIQRG AVYAENCILA AFSICQKKAN LRAQ (1-273 aa encoded by BC022295)

Target Information

LOX-1 (lectin-like oxidized LDL receptor -1) is a 40-50 kDa type II membrane glycoprotein class E scavenger receptor expressed by endothelial cells, macrophages, activated platelets and smooth muscle cells. LOX-1 binds to a wide range of ligands, including oxidized low-density lipoprotein (oxLDL), hypochlorite modified high-density lipoprotein (HDL), aged /apoptotic cells, activated platelets and bacteria, reflecting its versatile physiological functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fenretinide Inhibits Neutrophil Recruitment and IL-1β Production in Aspergillus fumigatus Keratitis.

Cornea

Zhao W,Che C,Liu K,Zhang J,Jiang N,Yuan K,Zhao G

Sat Dec 01 00:00:00 EST 2018

LOX-1 is a poor prognostic indicator and induces epithelial-mesenchymal transition and metastasis in pancreatic cancer patients.

Cellular oncology (Dordrecht)

Zhang J,Zhang L,Li C,Yang C,Li L,Song S,Wu H,Liu F,Wang L,Gu J

Thu Feb 01 00:00:00 EST 2018

LOX-1 is a poor prognostic indicator and induces epithelial-mesenchymal transition and metastasis in pancreatic cancer patients.

Cellular oncology (Dordrecht)

Zhang J,Zhang L,Li C,Yang C,Li L,Song S,Wu H,Liu F,Wang L,Gu J

Thu Feb 01 00:00:00 EST 2018

Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet.

PloS one

Zhang M,Zhao H,Cai J,Li H,Wu Q,Qiao T,Li K

Fri Nov 03 00:00:00 EDT 2017

Chronic administration of mitochondrion-targeted peptide SS-31 prevents atherosclerotic development in ApoE knockout mice fed Western diet.

PloS one

Zhang M,Zhao H,Cai J,Li H,Wu Q,Qiao T,Li K

Fri Nov 03 00:00:00 EDT 2017

Up-regulation of OLR1 expression by TBC1D3 through activation of TNFα/NF-κB pathway promotes the migration of human breast cancer cells.

Cancer letters

Wang B,Zhao H,Zhao L,Zhang Y,Wan Q,Shen Y,Bu X,Wan M,Shen C

Wed Nov 01 00:00:00 EDT 2017

Mitochondrion-Targeted Peptide SS-31 Inhibited Oxidized Low-Density Lipoproteins-Induced Foam Cell Formation through both ROS Scavenging and Inhibition of Cholesterol Influx in RAW264.7 Cells.

Molecules (Basel, Switzerland)

Hao S,Ji J,Zhao H,Shang L,Wu J,Li H,Qiao T,Li K

Tue Dec 01 00:00:00 EST 2015

Bioinformatics

Protein Aliases: C-type lectin domain family 8 member A; hLOX 1; hLOX-1; hLOX1; Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1; LOX 1; LOX-1; ox LDL receptor 1; Ox-LDL receptor 1; oxidized low density lipoprotein (lectin-like) receptor 1; Oxidized low-density lipoprotein receptor 1; Oxidized low-density lipoprotein receptor 1, soluble form; scavenger receptor class E, member 1; sLOX 1; soluble LOX 1

Gene Aliases: CLEC8A; LOX1; LOXIN; OLR1; SCARE1; SLOX1

UniProt ID: (Human) P78380

Entrez Gene ID: (Human) 4973

Function(s)

proteolysis receptor-mediated endocytosis inflammatory response leukocyte cell-cell adhesion blood circulation cell death lipoprotein metabolic process response to hydrogen peroxide leukocyte migration

Process(es)

low-density lipoprotein receptor activity protein binding carbohydrate binding