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Invitrogen
ONECUT2 Polyclonal Antibody
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Product Details
PA5-113643
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N terminal region of human ONECUT2 (aa 108-157).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TSMASILDGG DYRPELSIPL HHAMSMSCDS SPPGMGMSNT YTTLTPLQPL
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rat: 93%
Target Information
ONECUT2 is a member of the transcription factors of the ONECUT class, whose prototype is hepatocyte nuclear factor (HNF)-6. The distribution of OC-2 mRNA in humans is tissue-restricted, the strongest expression being detected in the liver and skin. ONECUT2 participates in the network of transcription factors required for liver differentiation and metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepatocyte nuclear factor 6-beta; HNF-6-beta; HNF-6B; OC-2; One cut domain family member 2; One cut homeobox 2; onecut 2; ONECUT-2 homeodomain transcription factor; Transcription factor ONECUT-2
Gene Aliases: HNF6B; OC-2; OC2; ONECUT2
UniProt ID: (Human) O95948
Entrez Gene ID: (Human) 9480
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific double-stranded DNA binding
liver development
regulation of cell-matrix adhesion
epithelial cell development
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
anatomical structure morphogenesis
organ morphogenesis
cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
pancreas development
endocrine pancreas development
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
peripheral nervous system neuron development
cilium morphogenesis
mesenchymal stem cell migration
positive regulation of mesenchymal stem cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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