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Invitrogen
OPA1 Polyclonal Antibody
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Product Details
PA1-16991
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Mouse,
Pig,
Rat,
Zebrafish
Published species
Goat,
Human,
Mouse,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an internal region within residues 500-600 of human OPA1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody shares 100% sequence homology with primate, 94% with zebrafish.
Suggested positive control: human brain protein.
Target Information
OPA1 is a dynamin-related GTPase that is critical for the maintenance of mitochondrial morphology and mtDNA. The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous dominant trait that causes reduced visual clarity and sometimes blindness. The disease usually begins in childhood and increases in severity throughout the life of affected individuals. Usually, this phenotype is attributed to the degeneration of optic nerve fibers. Interestingly, the same type of nerve degeneration seems to be partially causative of certain schizophrenia characteristics. OPA1 dysfunction also seems to be implicated in this case; mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1. The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dynamin-like 120 kDa protein, mitochondrial; Dynamin-like GTPase OPA1, mitochondrial; dynamin-like guanosine triphosphatase; Large GTP-binding protein; LargeG; mitochondrial dynamin-like GTPase; mitochondrial OPA1; opa1 {ECO:0000312|EMBL:AAI11072.1}; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1-like protein; Optic atrophy protein 1; Optic atrophy protein 1 homolog; RN protein
Gene Aliases: 1200011N24Rik; AI225888; AI847218; BERHS; fk62d06; KIAA0567; largeG; lilr3; MGM1; mKIAA0567; MTDPS14; NPG; NTG; OPA1; RCJMB04_1m16; wu:fb77a10; wu:fk62d06; zgc:92092
UniProt ID: (Chicken) Q5F499, (Human) O60313, (Rat) Q2TA68, (Mouse) Q8BLL3, (Zebrafish) Q5U3A7
Entrez Gene ID: (Pig) 100522705, (Chicken) 424900, (Human) 4976, (Rat) 171116, (Mouse) 74143, (Zebrafish) 492332
mitochondrial fission
dynamin polymerization involved in mitochondrial fission
apoptotic process
mitochondrial fusion
GTP metabolic process
organelle fission
membrane fusion
membrane tubulation
mitochondrial genome maintenance
mitochondrion organization
inner mitochondrial membrane organization
visual perception
positive regulation of mitochondrial fusion
positive regulation of neuron maturation
axonal transport of mitochondrion
negative regulation of release of cytochrome c from mitochondria
cellular senescence
positive regulation of dendrite development
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
neural tube closure
aging
metabolic process
negative regulation of intrinsic apoptotic signaling pathway
response to stimulus
chordate embryonic development
ventricular cardiac muscle cell development
mitochondrion morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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