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Product Details
PA5-98030
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:5,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
ELISA (ELISA) |
Assay-Dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant Human Oligophrenin-1 protein (1-270AA) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.18 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C or -80°C if preferred |
RRID |
AB_2812644 |
Target Information
Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mental retardation, X-linked 60; Oligophrenin-1; oligophrenin-1, Rho-GTPase activating protein
Gene Aliases: ARHGAP41; MRX60; OPHN1; OPN1
UniProt ID: (Human) O60890
Entrez Gene ID: (Human) 4983
Molecular Function:
GTPase-activating protein
substrate-dependent cell migration, cell extension
signal transduction
nervous system development
axon guidance
actin cytoskeleton organization
regulation of endocytosis
positive regulation of GTPase activity
synaptic vesicle endocytosis
regulation of small GTPase mediated signal transduction
regulation of synaptic transmission, glutamatergic
negative regulation of proteasomal protein catabolic process
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