PA1-24534 detects Opioid Receptor, Kappa 1 in Human samples.
PA1-24534 has been successfully used in Immunohistochemistry procedures. Positive control: rat brain.
The PA1-24534 immunogen is a synthetic peptide, KLH conjugated, corresponding to the second extracellular domain of human kappa-1 Opioid Receptor. Sequence identity/similarity to mouse: 94/100%. rat: 94/100%.
Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles.
KOR1, an Opioid Receptor, plays a modulatory role in specific aspects of opioid function such as the control of pain. Its endogenous ligand, dynorphin A, is an important neurotransmitter in the central and peripheral nervous systems. KOR1 is believed to mediate sedation, analgesia, and diuresis. KOR1 has been reported to be expressed in the central and peripheral nervous systems, placenta, uterus, breast, and blood. ESTs have been isolated from placenta and prostate libraries.
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Protein Aliases: K-OR-1; kappa opioid receptor; Kappa-type opioid receptor; Opiate receptor, kappa-1; opioid receptor, kappa 1
Gene Aliases: K-OR-1; KOR; KOR-1; OPRK; OPRK1
UniProt ID: (Human) P41145
Entrez Gene ID: (Human) 4986