IHC (P) analysis shows positive staining of KOR in human brain.
WB analysis shows KOR in glycoprotein-enriched fractions from mock transfected or KOR overexpressing 293 cells.
While KOR has a theoretical MW of ~ 43kD, the observed band in a WB runs at ~60kD due to enrichment of the glycosylated receptor.
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. G-protein coupled opioid receptor functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. KORs are widely distributed in the brain, spinal cord and pain neurons.
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Protein Aliases: K-OR-1; Kappa Opioid Receptor; Kappa-Type Opioid Receptor; KOPR1; KOR; KOR-1; Opiate receptor, kappa-1; Opioid Receptor Kappa; Opioid Receptor Kappa 1; opioid receptor, kappa 1; OPRK
Gene Aliases: K-OR-1; KOR; KOR-1; OPRK; OPRK1
UniProt ID: (Human) P41145
Entrez Gene ID: (Human) 4986