Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
OPRK1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 2
OPRK1 Antibody (PA3-028) in IHC (P)
Immunohistochemistry analysis of KOR was performed on human brain tissue. To expose target proteins, antigen retrieval was performed by microwaving tissues for 20 minutes in 10mM sodium citrate buffer (pH 6.0). Tissue slides were probed with a KOR polyclonal antibody (Product # PA3-028) at a dilution of 1:3000, overnight at 4C in a humidified chamber. Tissues were washed, and detection was performed using a... View More
Product Details
PA3-028
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated Cys-RVRNTVQDPAYLRDIDGMNKPV
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
IHC (P) analysis shows positive staining of KOR in human brain.
WB analysis shows KOR in glycoprotein-enriched fractions from mock transfected or KOR overexpressing 293 cells.
While KOR has a theoretical MW of ~ 43kD, the observed band in a WB runs at ~60kD due to enrichment of the glycosylated receptor.
Target Information
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: K-OR-1; kappa opioid receptor; Kappa-type opioid receptor; KOPR1; Opiate receptor, kappa-1; opioid receptor, kappa 1; Ork1
Gene Aliases: K-OR-1; KOR; KOR-1; OPRK; OPRK1
UniProt ID: (Human) P41145
Entrez Gene ID: (Human) 4986
immune response
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
chemical synaptic transmission
sensory perception
behavior
locomotory behavior
response to radiation
sensory perception of pain
adenylate cyclase-inhibiting opioid receptor signaling pathway
response to insulin
positive regulation of dopamine secretion
negative regulation of luteinizing hormone secretion
opioid receptor signaling pathway
positive regulation of locomotion
maternal behavior
eating behavior
response to morphine
response to estrogen
estrous cycle
response to ethanol
regulation of saliva secretion
behavioral response to cocaine
sensory perception of temperature stimulus
defense response to virus
regulation of sensory perception of pain
cellular response to lipopolysaccharide
positive regulation of p38MAPK cascade
positive regulation of potassium ion transmembrane transport
regulation of aerobic respiration
response to acrylamide
conditioned place preference
regulation of energy homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support