Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%) Marmoset, Bat, Dog, Bovine, Hamster, Panda, Horse, Rabbit, Guinea pig (94%).
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: K-OR-1; kappa 1; Kappa opioid receptor; kappa-1; Kappa-type opioid receptor; KOR; KOR-1; Opiate receptor; Opiate receptor, kappa-1; Opioid receptor; Opioid receptor kappa; opioid receptor, kappa 1; OPRK; OPRK1; Ork1
Gene Aliases: K-OR-1; KOR; KOR-1; OPRK; OPRK1; Ror-d