PA1-4561 detects mu Opioid Receptor from human, mouse, and rat samples.
PA1-4561 has been successfully used in Western blotting applications. This antibody will detect a dominant band of ~46 kDa representing the monomer form of MOR-1, and may also detect dimmers or trimers as heterodimerization and homodimerization is common
The PA1-4561 immunogen is a synthetic peptide comprising residues N(386) H Q L E N L E A E T A P L P(400) of human, mouse and rat MOR-1.
G protein-coupled receptors (GPCRs) are the largest family of membrane receptors that activate intracellular signaling cascades and undergo endocytosis, recycling, or degradation upon stimulation. The mu, delta and kappa opioid receptors are GPCRs of the nervous system, which control pain, stree, and addictive behaviors. The mu opioid receptor (MOR-1) is a high-affinity receptor for enkephalins and beta- endorphins with low affinity for dynorphins. The opiate alkaloids morphine and codeine bind to MOR-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: M-OR-1; MOP; MOP receptor; MOR-1; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant mMOR-1Z; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; Mu-type opioid receptor; MUOR1; Opioid receptor B; opioid receptor, mu 1; Opioid Receptor, Mu-1; OPRM1
Gene Aliases: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; MORA; muOR; OPRM; OPRM1; Oprrm1; Ror-b