Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Dog, Bat, Bovine, Hamster, Elephant, Panda, Pig (100%).
The opioid receptors are G-protein coupled, seven-transmembrane domain receptors for enkephalins, endorphins, and dynorphins. Three different opioid receptor subtypes (kappa , delta, and mu) were first identified by their different selectivities for various naturally occurring alkaloid opioid ligands, and subsequently confirmed by molecular cloning. The amino acid sequences of the opioid receptor subtypes are ~70% homologous, and are similar to somatostatin receptors (SSTRs) showing ~40 % homology with SSTR1. G-protein binding is thought to occur at the third intracellular loop of the opioid receptors, which is also the location of consensus sequences for phosphorylation of the receptor. Interestingly, the genes encoding the specific receptor subtypes are found on different chromosomes in both the human and mouse genomes. The mu opioid receptor is widely distributed throughout the central nervous system, with higher levels found in the periaqueductal gray region and in the superficial dorsal horn of the spinal cord. The mu receptor demonstrates high affinity to enkephalins and beta-endorphin, and low affinity to dynorphins. The mu opioid receptor is also the high affinity binding protein for the opiate alkaloids such as morphine, codeine, and methadone.
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Protein Aliases: HMOP; KIAA0403; LMOR; M-OR-1; MOP; MOR; MOR-1; MOR-1C; MOR1; mu 1; Mu opiate receptor; Mu opioid receptor; Mu opioid receptor hMOR-1a; Mu-type opioid receptor; Opioid mu receptor; Opioid mu-type receptor; Opioid receptor; opioid receptor, mu 1; OPRM; OPRM1
Gene Aliases: LMOR; M-OR-1; MOP; MOR; MOR1; OPRM; OPRM1
UniProt ID: (Human) P35372
Entrez Gene ID: (Human) 4988