PA5-30475 targets ORC3L in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30475 immunogen is recombinant fragment corresponding to a region within amino acids 48 and 315 of Human ORC3L.
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The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.
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Protein Aliases: Drosophila; homolog of latheo; homolog of latheo, Drosophila; LAT; LATHEO; ORC3L; origin recognition complex; Origin recognition complex subunit 3; Origin recognition complex subunit Latheo; origin recognition complex, subunit 3 honolog; subunit 3 honolog; subunit 3-like
Gene Aliases: LAT; LATHEO; ORC3; ORC3L
UniProt ID: (Human) Q9UBD5
Entrez Gene ID: (Human) 23595